Studies of the Pituitary-Adrenocortical System in the Fetal Rat

摘要: The pituitary-adrenocortical system of 21- to 22-day-old rat fetuses was investigated. 1. Adrenal ascorbic acid depletion caused by stressful stimulus the same in hypophysectomized rats as those normal rats. degree (15% 1 hr) also occurred maintained ex utero at room temperature during 1-hr period. 2. Fetal adrenals incubated Krebs- Ringer bicarbonate buffer produced corticosterone rate did from adult However, fetal were found be more sensitive ACTH vitro than 3. pituitaries increased production addition pitressin medium (1 mU/ml) had no effect on adrenal tissue with or without hypophyses. These data show that term are stimulated pituitary. In addition, a definite functio...