作者: Kazumi Uchida , Peter V Danenberg , Kathleen D Danenberg , Jean L Grem
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摘要: Background Over-expression of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) in tumor tissue is associated with insensitivity to 5-fluorouracil (5-FU). Over-expression ERCC1 correlates oxaliplatin (OX) therapy, while high thymidine phosphorylase (TP) levels predict for increased sensitivity capecitabine (Xel).