Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine

作者: Kazumi Uchida , Peter V Danenberg , Kathleen D Danenberg , Jean L Grem

DOI: 10.1186/1471-2407-8-386

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摘要: Background Over-expression of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) in tumor tissue is associated with insensitivity to 5-fluorouracil (5-FU). Over-expression ERCC1 correlates oxaliplatin (OX) therapy, while high thymidine phosphorylase (TP) levels predict for increased sensitivity capecitabine (Xel).

参考文章(34)
Nicholas S. BROWN, Roy BICKNELL, THYMIDINE PHOSPHORYLASE, 2-DEOXY-D-RIBOSE AND ANGIOGENESIS Biochemical Journal. ,vol. 334, pp. 1- 8 ,(1998) , 10.1042/BJ3340001
Peter V. Danenberg, Jan Brabender, Ann L. Jackman, G. Wynne Aherne, David Cunningham, Kathleen D. Danenberg, Anthea Hardcastle, Hugo E. R. Ford, A. David McVicar, Keith McCarthy, David C. Farrugia, Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed. Clinical Cancer Research. ,vol. 9, pp. 792- 801 ,(2003)
Carlo Aschele, Domizia Debernardis, Stefania Casazza, Giovanna Antonelli, Gianni Tunesi, Chiara Baldo, Rita Lionetto, Frank Maley, Alberto Sobrero, Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil- based chemotherapy Journal of Clinical Oncology. ,vol. 17, pp. 1760- 1770 ,(1999) , 10.1200/JCO.1999.17.6.1760
C G Leichman, H J Lenz, L Leichman, K Danenberg, J Baranda, S Groshen, W Boswell, R Metzger, M Tan, P V Danenberg, Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. Journal of Clinical Oncology. ,vol. 15, pp. 3223- 3229 ,(1997) , 10.1200/JCO.1997.15.10.3223
A. Jemal, R. Siegel, E. Ward, T. Murray, J. Xu, M. J. Thun, Cancer statistics, 2007. CA: A Cancer Journal for Clinicians. ,vol. 57, pp. 43- 66 ,(2007) , 10.3322/CANJCLIN.57.1.43
Tatsuo Morita, Atsushi Matsuzaki, Akihiko Tokue, Enhancement of sensitivity to capecitabine in human renal carcinoma cells transfected with thymidine phosphorylase cDNA International Journal of Cancer. ,vol. 92, pp. 451- 456 ,(2001) , 10.1002/IJC.1212