Identification of genes required for the spontaneous repair of partial-thickness cartilage defects in immature rats.
作者： Naoshi Ikegawa , Takahisa Sasho , Satoshi Yamaguchi , Masahiko Saito , Ryuichiro Akagi
DOI: 10.3109/03008207.2015.1121250
关键词:
摘要: ABSTRACTPurpose: Our previous study showed that partial-thickness articular cartilage defects (PTCDs) created in immature rats spontaneously healed to resemble normal hyaline cartilage, but of mature did not. To identify molecules involved the spontaneous repair observed this model, gene expression was compared between PTCD and sham-operated rats. Materials Methods: Six sets comparisons were made at 12, 24, 48 hours after creation PTCDs using microarrays. All genes upregulated 12 selected for further analysis if their pattern not irregular such diminished 24 re-upregulated hours. Relationships among through above steps analyzed Ingenuity Pathway Analysis (IPA) software. After deriving networks, important narrowed down by location within a network. Genes regarded ...
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