Extracellular N-Acetylaspartate in Human Traumatic Brain Injury
作者： Richard J Shannon , Susan van der Heide , Eleanor L Carter , Ibrahim Jalloh , David K Menon
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摘要: Abstract N-acetylaspartate (NAA) is an amino acid derivative primarily located in the neurons of adult brain. The function NAA incompletely understood. Decrease brain tissue presently considered symptomatic and a potential biomarker acute chronic neuropathological conditions. aim this study was to use microdialysis investigate behavior extracellular (eNAA) levels after traumatic injury (TBI). Sampling for performed using cerebral catheters (M Dialysis 71) perfused at 0.3 μL/min. Extracellular measured microdialysates by high-performance liquid chromatography 30 patients with severe TBI comparison, radiographically “normal” areas six non-TBI neurosurgical patients. We established detailed temporal eNAA profile eight Microdialysate concentrations glucose, lactate, pyruvate, glutamate, glycerol were on ISCUS clinical analyzer...
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