GC-MS based metabolomics of CSF and blood serum: Metabolic phenotype for a rat model of cefoperazone-induced disulfiram-like reaction.

摘要: Cefoperazone is most popularly used in the treatment of complicated infections clinically. Concomitant ingestion ethnaol and cefoperazone may cause a disulfiram-like reaction. However, very little known about possible interactions between an alcohol with regard to induction Study metabolic impact cotreatment on animals can facilitate identification markers relevant In this study, serum cerebrospinal fluid (CSF) metabolites from Sprague-Dawley rats were profiled using gas chromatography mass spectrometry. Serum levels valine, leucine, glycine, palmitelaidic acid, 2-hydroxyisobutyrate combination application group significantly higher than those control; while alanine pyruvate deceased group. Most TCA intermediates, glutamate aspartate had lower CSF level group, except citrate. addition, carbohydrates, ethylmalonate N-acetylaspartate compared control These results highlight concomitant generated reaction by way disrupting normal pathway. magnifes ethanol-induced impairment cycle metabolism, thereby affects energy metabolism neural transmission.