Severe acute respiratory syndrome coronavirus 3C‐like protease‐induced apoptosis
作者： Cheng-Wen Lin , Kuan-Hsun Lin , Tsung-Han Hsieh , Shi-Yi Shiu , Jeng-Yi Li
DOI: 10.1111/J.1574-695X.2006.00045.X
关键词:
摘要: The pathogenesis of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is an important issue for the treatment and prevention syndrome. Recently, SARS-CoV has been demonstrated to induce cell apoptosis in Vero-E6 cells. possible role 3C-like protease (3CLpro) virus-induced characterized this study. Growth arrest via caspase-3 caspase-9 activities were 3CLpro-expressing human promonocyte fluorescence intensity dihydrorhodamine 123 staining indicated that cellular reactive oxygen species markedly increased Moreover, vivo signalling pathway assay 3CLpro activation nuclear factor-kappa B-dependent reporter, but inhibited activator protein-1-dependent transcription. This finding likely be responsible apoptotic signalling.
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