Preparation of Caffeic Acid Phenethyl Ester-Incorporated Nanoparticles and Their Biological Activity
作者： Hyo-Young Lee , Young-Il Jeong , Eun Jin Kim , Kyung Dong Lee , Seon-Hee Choi
DOI: 10.1002/JPS.24278
关键词:
摘要: ABSTRACT: The aim of this study is to fabricate caffeic acid phenethyl ester (CAPE)-incorporated nanoparticles using methoxy poly(ethylene glycol)- b -poly(e-caprolactone) (CE) copolymer and their antitumor activity against pulmonary metastasis model CT26 colon carcinoma cells. CAPE-incorporated showed spherical shapes having small diameters less than 300 nm CAPE was continuously released from CE over 4 days. polymeric micelles properly inhibited proliferation induced apoptosis cells as well itself. Furthermore, they similar anti-invasive antimigrative effect at in vitro compared with itself, indicating that have least equivalent anticarcinogenic At nude mouse, superior antimetastatic efficacy against, is, control treatment significant increase lung weight because the tumor cells, whereas or We suggest a promising candidate for chemotherapeutic agent. © 2014 Wiley Periodicals, Inc. American Pharmacists Association J Pharm Sci 104:144–154, 2015
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