Vitamin D production depends on ultraviolet-B dose but not on dose rate: a randomized controlled trial.
作者： Morten K.B. Bogh , Anne V. Schmedes , Peter A. Philipsen , Elisabeth Thieden , Hans Christian Wulf
DOI: 10.1111/J.1600-0625.2010.01201.X
关键词:
摘要: Ultraviolet-B (UV-B) radiation increases serum vitamin D level expressed as 25-hydroxyvitamin D(3) (25(OH)D), but the dose-response relationship and importance of dose rate is unclear. Of 172 fair-skinned persons screened for 25(OH)D, 55 with insufficient baseline 25(OH)D≤50 nm (mean 31.2 nm) were selected randomized to one 11 groups five participants. Each group was exposed four different UV-B doses: 0.375, 0.75, 1.5 or 3.0 standard erythema (SED) 1, 5, 10 20 min. All participants had sessions 2- 3-day interval 24% their skin exposed. Skin pigmentation 25(OH)D measured before after irradiations. The increase in exposure (adjusted 25(OH)D) positively correlated (P=0.001; R(2) =0.176) not (1-20 min). increased response treatments 3 SED 24.8 on average 14.2 just 0.375 SED. In conclusion, depends Further, a significant achieved very low dose.
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