Effective bactericidal activity of tobramycin and vancomycin eluted from acrylic bone cement

摘要: We studied the bioactivity of vancomycin and tobramycin eluted from methylmethacrylate bone cement. Aliquots drainage were obtained at 1, 6, 12 24 hours following total hip prosthetic implantation with vancomycin-tobramycin-loaded cement in 3 patients. The samples analyzed fluorescence polarization immunoassay bioassay, using group B streptococcus for Escherichia coli tobramycin. These bacteria selected due to effectiveness poor against conversely E. coli. immunodetection averaged 14 (1 hour), 9 (6 hours), 10 (12 hours) 11 _6;g/mL (24 hours). bioassay 47, 36, 79 41 (p = 0.03). 43, 21, 18 _6;g/mL; 30, 15, 15 0.1). Both antibiotics a highly effective bactericidal activity. Our findings indicate that presence has synergis...