Novel Therapies Against Aggressive and Recurrent Epithelial Cancers by Molecular Targeting Tumor- and Metastasis-Initiating Cells and Their Progenies

摘要: A growing body of experimental evidence has revealed that the highly tumorigenic cancer stem/progenitor cells endowed with stem cell-like properties might be responsible for initiation and progression numerous aggressive epithelial cancers into locally invasive, metastatic incurable disease states. The malignant transformation tissue-resident adult or their progenies migrating resistance to current therapies have been associated high expression levels specific oncogenic products drug resistance-associated molecules. In this regard, we describe cascades are frequently activated in versus differentiated during early late stages progression. emphasis is on growth factor signaling pathways involved behavior prostate pancreatic progenies. Of clinical interest, potential molecular therapeutic targets eradicate tumor- metastasis-initiating develop new effective combination against advanced also described.