Characterization of the low pH/low nutrient-resistant LNCaP cell subline LNCaP-F10
作者： KAZUHIRO IGUCHI , YURI HAYAKAWA , KENICHIRO ISHII , KAORU MATSUMOTO , SHIGEYUKI USUI
DOI: 10.3892/OR.2012.2039
关键词:
摘要: Intratumoral regions of low extracellular pH and nutrition are common features solid tumors. Although cancer cells normally die when they removed from their environment, a small population survive. In the present study, subline LNCaP-F10, prostate cell line LNCaP, was isolated its pH/low nutrient-resistant properties were examined. LNCaP-F10 grown under low-pH/low-nutrient conditions, which caused death LNCaP cells. The associated with oligonucleosomal DNA fragmentation poly (ADP-ribose) polymerase (PARP) cleavage, indicating that induced apoptosis in these Significant differences expression BCL2, BIRC5 DAPK1 detected between Tumor growth by implantation into renal subcapsular space nude mice absence or presence stromal stimulation greater than resistant to an environment in vitro, displayed malignant potential in vivo.
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