F-box proteins involved in cancer-associated drug resistance.
作者： Jian Gong , Yuqian Zhou , Deliang Liu , Jirong Huo
DOI: 10.3892/OL.2018.8500
关键词:
摘要: The ubiquitin proteasome system (UPS) regulated human biological processes through the appropriate and efficient proteolysis of cellular proteins. F-box proteins are vital components SKP1-CUL1-FBP (SCF)-type E3 ligases that determine substrate specificity. As have ability to control degradation several crucial protein targets associated with drug resistance, dysregulation these may lead induction chemoresistance in cancer cells. Chemotherapy is one most conventional therapeutic approaches treatment patients cancer. However, its exclusive application clinical settings restricted due development chemoresistance, which typically results failure. Therefore, overcoming resistance considered as critical issues researchers clinician oncology face. present review serves provide a comprehensive overview their possible well correlation chemosensitization article also presents an integrated representation complex regulatory mechanisms responsible for lay foundation explore sensible candidate drugs intervention.
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