Controlled Release Carbamazepine: Cognitive Side Effects in Patients with Epilepsy
作者： A. P. Aldenkamp , W. C. J. Alpherts , M. C. Moerland , N. Ottevanger , J. A. P. Van Parys
DOI: 10.1111/J.1528-1157.1987.TB03679.X
关键词:
摘要: The treatment of epilepsy with carbamazepine (CBZ) may be hampered by cognitive side effects. These effects are thought to related pharmacokinetic properties the drug. serum concentration CBZ is characterized rapid absorption and a short half-life, which lead considerable fluctuation level between doses. Cognitive defects result from peak levels: periods high concentration. In single-blind crossover design, performance was compared in three conditions. All patients were first tested steady state conventional CBZ. then assigned randomly either CBZ-controlled release (CR) or condition administered same tablet form dose frequency as CR. Psychological tests four times daily, immediately after samples taken. A nonmedication control group following test scheme obtain standards for evaluation changes during day. systematic tendency found toward higher CR condition. This especially evident memory accuracy visual information processing. results repeated procedure show that smoothing effect on fluctuations more stable pattern functioning
sci-hub.se 参考文章(13)
Ernst A. Rodin, Steve Schmaltz, Gail Twitty, INTELLECTUAL FUNCTIONS OF PATIENTS WITH CHILDHOOD-ONSET EPILEPSY Developmental Medicine & Child Neurology. ,vol. 28, pp. 25- 33 ,(2008) , 10.1111/J.1469-8749.1986.TB03826.X
DJ Gannaway, GE Mawer, Serum phenytoin concentration and clinical response in patients with epilepsy British Journal of Clinical Pharmacology. ,vol. 12, pp. 833- 839 ,(1981) , 10.1111/J.1365-2125.1981.TB01316.X
C. B. DODRILL, A. S. TROUPIN, Psychotropic effects of carbamazepine in epilepsy A double‐blind comparison with phenytoin Neurology. ,vol. 27, pp. 1023- 1023 ,(1977) , 10.1212/WNL.27.11.1023
D. G. Andrewes, J. G. Bullen, L. Tomlinson, R. D. C. Elwes, E. H. Reynolds, A comparative study of the cognitive effects of phenytoin and carbamazepine in new referrals with epilepsy. Epilepsia. ,vol. 27, pp. 128- 134 ,(1986) , 10.1111/J.1528-1157.1986.TB03515.X
M.C. Moerland, A.P. Aldenkamp, W.C.J. Alpherts, A neurophysical test battery for the Apple II-E International Journal of Human-computer Studies \/ International Journal of Man-machine Studies. ,vol. 25, pp. 453- 467 ,(1986) , 10.1016/S0020-7373(86)80071-2
M. Dam, J. Christiansen, C. B. Kristensen, Aa. Helles, A. Jaegerskou, M. Schmiegelow, Carbamazepine: a clinical biopharmaceutical study. European Journal of Clinical Pharmacology. ,vol. 20, pp. 59- 64 ,(1981) , 10.1007/BF00554668
P J Thompson, M R Trimble, Anticonvulsant serum levels: relationship to impairments of cognitive functioning. Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 46, pp. 227- 233 ,(1983) , 10.1136/JNNP.46.3.227
Josef Parnas, Lennart Gram, Helga Flachs, Psychopharmacological aspects of antiepileptic treatment. Progress in Neurobiology. ,vol. 15, pp. 119- 138 ,(1980) , 10.1016/0301-0082(80)90005-2
Michael R. Trimble, Pamela J. Thompson, Memory, anticonvulsant drugs and seizures. Acta Neurologica Scandinavica. ,vol. 64, pp. 31- 41 ,(2009) , 10.1111/J.1600-0404.1981.TB02360.X
C. Wikkelsø, C. Blomstrand, P. Nordquist, Cerebrospinal fluid investigations in multi-infarct dementia and senile dementia. Acta Neurologica Scandinavica. ,vol. 64, pp. 1- 11 ,(2009) , 10.1111/J.1600-0404.1981.TB04380.X