In vitro characterization of carbamazepine-loaded precifac lipospheres.
作者： Nahla S. Barakat , Alaa Eldeen B. Yassin
DOI: 10.1080/10717540500313661
关键词:
摘要: Lipospheres of carbamazepine were prepared by melt dispersion technique using Precifac ATO 5 in the various drug-lipid ratios. The resulting free-flowing lipospheres evaluated with respect to surface morphology, particle size distribution, encapsulation efficiency, and vitro release behavior. effect druglipid ratio, surfactant added, emulsion stabilizer, stirring speed also identified as key variables affecting formation discrete spherical drug rate. preparation conditions optimized 0.4% w/v span 20 (Hydrophilic-Lipophilic Balance, HLB = 8.6) a 1% gelatin solution stabilizer presence high level water. We found that ratio lipid affects spheres. incorporation efficiency was be at all loadings. Increasing lipid:drug produced more spherical, smooth, round lipospheres. All exhibited slow profiles dictating Higuchi mode release. saw higher sphere Precifac, slower is
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