Novel methods of antiepileptic drug delivery - polymer-based implants

摘要: Epilepsy is a neurological disorder characterised by spontaneous seizures. Over one third of patients receive insufficient benefit from oral anti-epileptic drug (AED) therapy, and continue to experience seizures whilst on medication. researchers are consequently seeking new ways deliver AEDs directly the seizure focus in brain order higher, more effective doses bypassing remainder body prevent side effects. The this review will be polymer-based implants, which polymeric devices loaded with AED that designed for implantation at achieve gradual, continuous release direct into region responsible Polymer-based implants produced epilepsy date based range polymers, both biodegradable non-biodegradable, simple materials development studies through investigations animal models epilepsy, varying degrees success. This describes methods employed manufacture compares their advantages potential appeal industry, results successes treatment epilepsy. We also discuss disadvantages hurdles overcome field, describe our predictions advances made field coming decade.