Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying

摘要: Cinnamon extract is associated to different health benefits but the active ingredients or pathways are unknown. Cinnamaldehyde (CIN) imparts characteristic flavor cinnamon and known be main agonist of transient receptor potential-ankyrin 1 (TRPA1). Here, expression TRPA1 in epithelial mouse stomach cells described. After receiving a single-dose CIN, mice significantly reduce cumulative food intake gastric emptying rates. Co-localization ghrelin enteroendocrine duodenum observed both vivo MGN3-1 cell line, secreting model, where incubation with CIN up-regulates Insulin genes. Ghrelin secreted culture medium was quantified following stimulation we observe that octanoyl total lower than control conditions. Additionally, obese fed for five weeks CIN-containing diet their body weight gain improve glucose tolerance without detectable modification insulin secretion. Finally, adipose tissue up-regulation genes related fatty acid oxidation observed. Taken together, results confirm anti-hyperglycemic anti-obesity effects opening new approach investigate how certain spice derived compounds regulate endogenous release therapeutic intervention.