Rapid purification of gold nanorods for biomedical applications.

摘要: Small gold nanorods (GNRs) with longitudinal plasmon absorption in the near-infrared window (700–900 nm) are of great interest for vivo optical applications (e.g., photothermal therapy) and their high-payload-to-carrier ratio drug delivery. Common synthetic strategies GNR production afford spherical cubical nanoparticles addition to desired GNRs. Thus, several methods have been proposed selective separation GNRs from reaction by-products. For example, centrifugation has used separate high aspect (AR) (AR > 4). However, it is difficult small sized low AR (AR ≤ 4) that particularly promising biomedical applications. Here, we describe a simple fast procedure 4, length 28 nm by-products. The shape achieved through according following steps: • Isolation all products excess cetyltrimethylammonium bromide first cycle centrifugation. • Optimization speed time by-products. • Shape second centrifugation. The effectiveness this documented.