Decreased expression of EFS is correlated with the advanced prostate cancer

作者: Selda Sertkaya , Syed Muhammad Hamid , Nihat Dilsiz , Lokman Varisli

DOI: 10.1007/S13277-014-2703-5

关键词:

摘要: Prostate cancer is the most frequently diagnosed malignant neoplasm in men developed countries. Although progression of prostate and processes invasion metastasis by tumor cells are comparatively well understood, genes involved these not fully determined. Therefore, a common area research interest identification novel molecules that processes. In present study, we have used silico experimental approaches to compare expression embryonal Fyn-associated substrate (EFS) between normal cancer. We showed EFS remarkably downregulated cells, compared cells. also found decreased due DNA methylation. addition, high important suppress behavior suggest should be considered as suppressor gene

参考文章(35)
Lisa M. Sapinoso, Jessica Wang-Rodriguez, John B. Welsh, Christopher A. Moskaluk, Suzanne G. Kern, Andrew I. Su, Henry F. Frierson, Garret M. Hampton, Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Research. ,vol. 61, pp. 5974- 5978 ,(2001)
LOKMAN VARISLI, Meta-analysis of the cell cycle related C12orf48 Biocell. ,vol. 37, pp. 11- 16 ,(2013) , 10.32604/BIOCELL.2013.37.011
Nadezhda Tikhmyanova, Joy L. Little, Erica A. Golemis, CAS proteins in normal and pathological cell growth control Cellular and Molecular Life Sciences. ,vol. 67, pp. 1025- 1048 ,(2010) , 10.1007/S00018-009-0213-1
Uma R Chandran, Changqing Ma, Rajiv Dhir, Michelle Bisceglia, Maureen Lyons-Weiler, Wenjing Liang, George Michalopoulos, Michael Becich, Federico A Monzon, None, Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process. BMC Cancer. ,vol. 7, pp. 64- 64 ,(2007) , 10.1186/1471-2407-7-64
T Barrette, A Pandey, AM Chinnaiyan, ONCOMINE: A Cancer Microarray Database and Integrated Data-Mining Platform Neoplasia. ,vol. 6, pp. 1- 6 ,(2004) , 10.1016/S1476-5586(04)80047-2
Lokman Varisli, Identification of new genes downregulated in prostate cancer and investigation of their effects on prognosis. Genetic Testing and Molecular Biomarkers. ,vol. 17, pp. 562- 566 ,(2013) , 10.1089/GTMB.2012.0524
LOKMAN VARISLI, Meta-analysis of the expression of the mitosis-related gene Fam83D Oncology Letters. ,vol. 4, pp. 1335- 1340 ,(2012) , 10.3892/OL.2012.925
S. Perwez Hussain, Curtis C. Harris, Inflammation and cancer: An ancient link with novel potentials International Journal of Cancer. ,vol. 121, pp. 2373- 2380 ,(2007) , 10.1002/IJC.23173