Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α

作者: Angela M. Fala , Juliana F. Oliveira , Douglas Adamoski , Juliana A. Aricetti , Marilia M. Dias

DOI: 10.1038/SREP12698

关键词:

摘要: Hypoxia-inducible transcription factors (HIF) form heterodimeric complexes that mediate cell responses to hypoxia. The oxygen-dependent stability and activity of the HIF-α subunits is traditionally associated post-translational modifications such as hydroxylation, acetylation, ubiquitination, phosphorylation. Here we report novel evidence showing unsaturated fatty acids are naturally occurring, non-covalent structural ligands HIF-3α, thus providing initial framework for exploring its exceptional role a lipid sensor under

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