Affinity and avidity in antibody-based tumor targeting.
作者： Stephen I. Rudnick , Gregory P. Adams
关键词:
摘要: … an inverse relationship between affinity and penetration (termed the … low affinity mAb was more homogenously distributed throughout the tumor than a mAb with a fivefold higher affinity…
liebertonline.com参考文章(48)
Kipriyanov Sm, Le Gall F, Recent advances in the generation of bispecific antibodies for tumor immunotherapy. Current Opinion in Drug Discovery & Development. ,vol. 7, pp. 233- 242 ,(2004)
John N. Weinstein, William van Osdol, Kenji Fujimori, An analysis of monoclonal antibody distribution in microscopic tumor nodules: consequences of a "binding site barrier". Cancer Research. ,vol. 51, pp. 4776- 4784 ,(1991)
Rakesh K. Jain, Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors. Cancer Research. ,vol. 50, ,(1990)
Ulrik B. Nielsen, James D. Marks, Louis M. Weiner, Gregory P. Adams, Targeting of Bivalent Anti-ErbB2 Diabody Antibody Fragments to Tumor Cells Is Independent of the Intrinsic Antibody Affinity Cancer Research. ,vol. 60, pp. 6434- 6440 ,(2000)
Matthew D. Scharff, Eric Z. Berkowitz, Lionel S. Zuckier, Quing Hua Zhao, Hou Fu Deng, Ronald J. Sattenberg, Influence of affinity and antigen density on antibody localization in a modifiable tumor targeting model. Cancer Research. ,vol. 60, pp. 7008- 7013 ,(2000)
D. M. Goldenberg, Gaik Lin Ong, L. B. Shih, M. J. Mattes, R. J. Kyriakos, K. Patel, The Fate of Antibodies Bound to the Surface of Tumor Cells in Vitro Cancer Research. ,vol. 52, pp. 835- 842 ,(1992)
Louis M Weiner, Fully human therapeutic monoclonal antibodies. Journal of Immunotherapy. ,vol. 29, pp. 1- 9 ,(2006) , 10.1097/01.CJI.0000192105.24583.83
John N. Weinstein, William van Osdol, The macroscopic and microscopic pharmacology of monoclonal antibodies. International Journal of Immunopharmacology. ,vol. 14, pp. 457- 463 ,(1992) , 10.1016/0192-0561(92)90176-L
Richard M. Neve, Ulrik B. Nielsen, Dmitri B. Kirpotin, Marie-Alix Poul, James D. Marks, Christopher C. Benz, Biological effects of anti-ErbB2 single chain antibodies selected for internalizing function. Biochemical and Biophysical Research Communications. ,vol. 280, pp. 274- 279 ,(2001) , 10.1006/BBRC.2000.4104
Peter J Hudson, Alexander A Kortt, High avidity scFv multimers; diabodies and triabodies Journal of Immunological Methods. ,vol. 231, pp. 177- 189 ,(1999) , 10.1016/S0022-1759(99)00157-X