Mutagenic bioassay of certain pharmacological drugs. I. Thiabendazole (TBZ).
作者： M.D. Mudry de Pargament , M. Labal de Vinuesa , I. Larripa
DOI: 10.1016/0165-1218(87)90107-8
关键词:
摘要: This report describes the chromosomal damage produced by 2-(4′-thiazolyl)benzimidazole or thiabendazole (TBZ) evaluated “in vivo” and vitro” cytogenetic tests. The doses assayed in adult mice sister-chromatid exchange (SCE) micronucleus tests were: 50, 100 200 mg/kg body weight; these are within range of those used human antihelminthic treatments. SCE frequency was increased only last dose (p < 0.05). A significant increase micronucleated cells shown 3 0.001). marked abnormal anaphase-telophase detected with two highest concentrations (0.60–0.24 μg/ml) p <0.01 <0.05 respectively. observed genotoxic effects this compound indicate that TBZ itself is a mutagenic agent.
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sci-hub.se 参考文章(21)
J.P. Seiler, The mutagenicity of benzimidazole and benzimidazole derivatives. II. Incorporation of benzimidazole into the nucleic acids of Escherichia coli. Mutation Research. ,vol. 17, pp. 21- 25 ,(1973) , 10.1016/0027-5107(73)90249-2
J. L. SIRLIN, J. JACOB, SEQUENTIAL AND REVERSIBLE INHIBITION OF SYNTHESIS OF RIBONUCLEIC ACID IN THE NUCLEOLUS AND CHROMOSOMES: EFFECT OF BENZAMIDE AND SUBSTITUTED BENZIMIDAZOLES ON DIPTERAN SALIVARY GLANDS. Nature. ,vol. 204, pp. 545- 547 ,(1964) , 10.1038/204545A0
Yukimasa Shiraishi, Avery A. Sandberg, Sister chromatid exchange in human chromosomes, including observations in neoplasia Cancer Genetics and Cytogenetics. ,vol. 1, pp. 363- 380 ,(1980) , 10.1016/0165-4608(80)90046-1
J.P. Seiler, Toxicology and genetic effects of benzimidazole compounds Mutation Research/Reviews in Genetic Toxicology. ,vol. 32, pp. 151- 167 ,(1975) , 10.1016/0165-1110(75)90004-4
J L Foster, P J Conroy, A J Searle, R L Willson, Metronidazole (Flagyl): characterization as a cytotoxic drug specific for hypoxic tumour cells British Journal of Cancer. ,vol. 33, pp. 485- 490 ,(1976) , 10.1038/BJC.1976.78
J.B. Speakman, H.L. Nirenberg, Mutagenicity of methyl benzimidazol-2-yl carbamate (MBC) towards Aspergillus nidulans (Eidam) Winter and Cladosporium cucumerinum Ellis & Arth. Mutation Research\/genetic Toxicology. ,vol. 88, pp. 45- 51 ,(1981) , 10.1016/0165-1218(81)90088-4
A. Ogata, H. Ando, Y. Kubo, K. Hiraga, Teratogenicity of thiabendazole in ICR mice Food and Chemical Toxicology. ,vol. 22, pp. 509- 520 ,(1984) , 10.1016/0278-6915(84)90220-5
W. Schmid, The micronucleus test. Mutation Research\/environmental Mutagenesis and Related Subjects. ,vol. 31, pp. 9- 15 ,(1975) , 10.1016/0165-1161(75)90058-8
I. Larripa, M. Mudry de Pargament, M. Labal de Vinuesa, Alicia Demattei, S. Brieux de Salum, In vivo and in vitro cytogenetic effects of the anti-tumor agent amsacrina (AMSA). Mutation Research\/genetic Toxicology. ,vol. 138, pp. 87- 91 ,(1984) , 10.1016/0165-1218(84)90089-2
A. C. HASTIE, Benlate-induced Instability of Aspergillus Diploids Nature. ,vol. 226, pp. 771- 771 ,(1970) , 10.1038/226771A0