The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program
作者： Kathleen H. Mavournin , David H. Blakey , Michael C. Cimino , Michael F. Salamone , John A. Heddle
DOI: 10.1016/0165-1110(90)90030-F
关键词:
摘要: The protocol recommended for the micronucleus assay in mammalian bone marrow has been revised and simplified. number of sample times reduced to one or two, depending upon dosing protocol. minimum cells be scored per treatment group increased 20,000 increase ability detect a doubling control frequency. Use both male female animals is recommended. Scoring micronuclei polychromatic erythrocytes peripheral blood included as variation assay. Published data on chemicals tested by have reviewed are summarized.
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