Effect of dopamine on intracellular sodium: a common pathway for pharmacological mechanism of action in bipolar illness.

摘要: Background. The pathogenesis of bipolar illness is unknown. A search for common mechanism action in effective medications has been utilized as a method to gain clues into mechanisms illness. recent increase reports documented efficacy first- and second-generation antipsychotics the control mania offers new opportunity insight pathophysiological disorder. Methods. selected critical review literature performed insights effect antipsychotic on ion regulation. Results. Dopamine D1 D2 receptor stimulation increases intracellular sodium concentrations. blockade normalizes stimulated concentrations, active pump expression. Conclusions. similar exercise previously suggested that lithium anticonvulsants reduce influx an activity-dependent manner. current suggests may have similar...