Analysis of ancient mycolic acids by using MALDI TOF MS: response to “Essentials in the use of mycolic acid biomarkers for tuberculosis detection” by Minnikin et al., 2010

作者: Laszlo Mark , Gergely Gulyas-Fekete , Antonia Marcsik , Erika Molnar , Gyorgy Palfi

DOI: 10.1016/J.JAS.2010.11.027

关键词:

摘要: The mycobacterial cell wall is consists of several long chain lipid and glycolipid components. Mycolic acids are major unique fraction the envelope mycobacteria that include ancient causative agents tuberculosis leprosy. analytical investigation these biomarker residues one most promising perspectives in field molecular paleopathology. Recently published this journal, Minnikin et al. present a systematic critique MALDI TOF MS analysis for determination mycolic acids, focusing on our previous paper. In study, mass spectrometric investigations by commonly used 2,5 DHB matrix were presented with comments to authors. On base recent results we have realize clinical protocols standards cannot directly be biomolecular paleopathological investigations. applicability very limited archaeology, thus scientific should adapted carefully bioarchaeological sciences.

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