Oxygen toxicity: role of hydrogen peroxide and iron.

作者: B. S. van Asbeck

DOI: 10.1007/978-1-4684-5730-8_38

关键词:

摘要: An important factor in tissue damage by toxic oxygen species is the ability to increase level of hydrogen peroxide. This inter mediate reduction not only a precursor with higher reactivity, such as hydroxyl radical, but it also controls process inflammatation its effect on synthesis vasoactive and chemotactic compounds. However, injury peroxide often, if always, depends availability catalytic iron.

参考文章(64)
R. Bolli, B. S. Patel, W. X. Zhu, P. G. O'Neill, C. J. Hartley, M. L. Charlat, R. Roberts, The iron chelator desferrioxamine attenuates postischemic ventricular dysfunction American Journal of Physiology-heart and Circulatory Physiology. ,vol. 253, ,(1987) , 10.1152/AJPHEART.1987.253.6.H1372
BS van Asbeck, JJ Marx, A Struyvenberg, JH van Kats, J Verhoef, Deferoxamine enhances phagocytic function of human polymorphonuclear leukocytes. Blood. ,vol. 63, pp. 714- 720 ,(1984) , 10.1182/BLOOD.V63.3.714.714
R W Egan, P H Gale, F.A Kuehl, Reduction of hydroperoxides in the prostaglandin biosynthetic pathway by a microsomal peroxidase. Journal of Biological Chemistry. ,vol. 254, pp. 3295- 3302 ,(1979) , 10.1016/S0021-9258(18)50758-4
M. Worwood, A. Jacobs, Iron in biochemistry and medicine ,(1981)
Charles Beauchamp, I. Fridovich, A mechanism for the production of ethylene from methional. The generation of the hydroxyl radical by xanthine oxidase. Journal of Biological Chemistry. ,vol. 245, pp. 4641- 4646 ,(1970) , 10.1016/S0021-9258(18)62842-X
J. H. Van Kats, J. J. M. Marx, A. Struyvenberg, B. S. Van Asbeck, J. Verhoef, Effect of iron (III) in the presence of various ligands on the phagocytic and metabolic activity of human polymorphonuclear leukocytes. Journal of Immunology. ,vol. 132, pp. 851- 856 ,(1984)
E Graf, J R Mahoney, R G Bryant, J W Eaton, Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site. Journal of Biological Chemistry. ,vol. 259, pp. 3620- 3624 ,(1984) , 10.1016/S0021-9258(17)43139-5
R Larsson, P Cerutti, Oxidants induce phosphorylation of ribosomal protein S6. Journal of Biological Chemistry. ,vol. 263, pp. 17452- 17458 ,(1988) , 10.1016/S0021-9258(19)77857-0