Glutathione Peroxidase 2 and Its Role in Cancer

摘要: Glutathione peroxidase 2 (GPx2) is preferentially expressed in the intestine, but also upregulated malignant epithelial cells of other organs. Whether this upregulation beneficial or detrimental for cancer cell growth and thus outcome cancer, unclear. The localization GPx2 crypt bases where stem proliferate under control Wnt pathway, points to a role self-renewal intestinal mucosa. This assumption supported by fact that target pathway. In knockout mice, apoptosis highly increased corroborating an involvement mucosal homeostasis. So far, appears be pro-carcinogenic either supporting escape directly maintaining proliferation. On hand, induced Nrf2 transcription factor which generally accepted induce endogenous defense systems. addition, counteracts COX-2 expression, thereby decreasing inflammation migration tumor cells. Collectively, may depend on stage cancer. likely inhibits initiation triggered oxidative damage chronic might prevent invasiveness metastasis, supports progression established tumors. Evidences dual are presented discussed.