NIR-driven graphitic-phase carbon nitride nanosheets for efficient bioimaging and photodynamic therapy.
作者： Lili Feng , Fei He , Guixin Yang , Shili Gai , Yunlu Dai
DOI: 10.1039/C6TB02232D
关键词:
摘要: Photodynamic therapy (PDT) is a noninvasive and promising anticancer modality that utilizes the photochemical reactions of photosensitizers, upon irradiation at specific wavelength, to yield reactive oxygen species (ROS) impair malignant cancer cells. As potential new two-dimensional layered photosensitizer, graphitic-phase carbon nitride (g-C3N4) exhibits high blue photoluminescence quantum good biocompatibility, but challenged by limited narrow absorption in near-infrared (NIR) region. Herein, order broaden its light utilization, unique original NIR excited nanocomposites (g-C3N4/UCNP NCs) for PDT based on g-C3N4 nanosheets combined with up-conversion nanoparticles (UCNPs) have been designed. UCNPs can efficiently convert ultraviolet visible emissions match well nanosheets. The swallowed up cells are able ROS suppress tumor cell growth then induce apoptosis laser excitation. This demonstrates g-C3N4/UCNP NCs as low-toxic biocompatible photosensitizer down/up-conversion luminescence imaging.
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