Detection of liver micrometastases from colorectal origin by perfusion CT in a rat model

摘要: Background Some patients with colorectal carcinoma have liver metastases (LMs) which cannot be detected by conventional imaging. This study aimed to assess whether hepatic perfusion changes induced micrometastases can computed tomography (CT). Methods LMs were produced in rats injecting cells into the portal vein. Perfusion CT was performed at microscopic (day 10), interval 17), and macroscopic stage 34). parameters using a dualinput one-compartmental model. Results Micro macro presented mean diameter of 0.5 2.6 mm, respectively. Compared controls, (1.1 mm) significant changes: decrease 42% (P=0.004) 41% (P=0.029) transit time an increase 292% (P=0.073) 240% (P=0.001) delay, Conclusions between 1.1 mm changes, CT. Such detection may help select propose chemotherapy primary tumor resection.