Experimental assessment of small intestinal submucosa as a bladder wall substitute.

摘要: Abstract Objectives This study determined the feasibility of promoting urinary bladder regeneration with porcine-derived small intestinal submucosa (SIS). Methods Twenty-two Sprague-Dawley rats underwent partial cystectomy immediate augmentation SIS. Bladders were harvested for histologic evaluation at 2, 4, 8, 12, 24, and 48 weeks. Results Histologically 2 weeks, there was infiltration graft material viable host cells consisting fibroblasts, macrophages, blood vessels covered by complete mucosal urothelium comprised transitional cells. During next 10 collagen formation maturation noted, end 12 SIS a mature matrix admixed thinly scattered disorganized smooth muscle bundles normal urothelium. At all three layers (urothelium, muscle, serosa) present grossly microscopically indistinguishable from rat bladder. Conclusions further supports concept suggests that may be augmentations.