Laminin modulates neuritogenesis of developing rat retinal ganglion cells through a protein kinase C-dependent pathway.
作者： Ricardo de Ary-Pires , Rafael Linden
DOI: 10.1002/(SICI)1097-4547(20000501)60:3<291::AID-JNR3>3.0.CO;2-Y
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摘要: Dissociated cells from rat retinae (P2-P21) were cultured to investigate interactions between brain-derived neurotrophic factor (BDNF), various substrates (poly-L-lysine, collagen, and laminin), protein kinases upon the neuritogenesis of retinal ganglion (RGCs). We found that BDNF-promoted was enhanced by forskolin in RGCs rats at P2-P21 plated on either poly-L-lysine or collagen. In contrast, cultures with a laminin substrate, enhancer effect observed only taken retina P2-P6. Laminin blocked enhancement BDNF-induced forskolin, P14 P21, induced tenfold increase kinase C (PKC) activity compared poly-L-lysine. This blockade reverted selective PKC inhibitor reproduced P14-P21 activator. Because axotomized need both BDNF regenerate, we suggest can hinder this simultaneous activation according developmentally regulated pattern. further propose model interaction optic pathways triggered BDNF, may be useful elucidating some biological effects seen regenerating axons.
sci-hub.se 参考文章(93)
L Somogyi, Z Lasić, S Vukičević, H Banfić, Collagen type IV stimulates an increase in intracellular Ca2+ in pancreatic acinar cells via activation of phospholipase C. Biochemical Journal. ,vol. 299, pp. 603- 611 ,(1994) , 10.1042/BJ2990603
S S Sim, J W Kim, S G Rhee, Regulation of D-myo-inositol 1,4,5-trisphosphate 3-kinase by cAMP-dependent protein kinase and protein kinase C. Journal of Biological Chemistry. ,vol. 265, pp. 10367- 10372 ,(1990) , 10.1016/S0021-9258(18)86955-1
P Forscher, LK Kaczmarek, JA Buchanan, SJ Smith, Cyclic AMP induces changes in distribution and transport of organelles within growth cones of Aplysia bag cell neurons The Journal of Neuroscience. ,vol. 7, pp. 3600- 3611 ,(1987) , 10.1523/JNEUROSCI.07-11-03600.1987
MP Villegas-Perez, M Vidal-Sanz, GM Bray, AJ Aguayo, Influences of peripheral nerve grafts on the survival and regrowth of axotomized retinal ganglion cells in adult rats The Journal of Neuroscience. ,vol. 8, pp. 265- 280 ,(1988) , 10.1523/JNEUROSCI.08-01-00265.1988
M Mawal-Dewan, J Henley, A Van de Voorde, J Q Trojanowski, V M Lee, The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases. Journal of Biological Chemistry. ,vol. 269, pp. 30981- 30987 ,(1994) , 10.1016/S0021-9258(18)47378-4
Jun-Lin Guan, Hong-Chen Chen, Signal Transduction in Cell–Matrix Interactions International Review of Cytology. ,vol. 168, pp. 81- 121 ,(1996) , 10.1016/S0074-7696(08)60883-9
J M Litersky, G V Johnson, Phosphorylation by cAMP-dependent protein kinase inhibits the degradation of tau by calpain. Journal of Biological Chemistry. ,vol. 267, pp. 1563- 1568 ,(1992) , 10.1016/S0021-9258(18)45982-0
Veit H. Höpker, Derryck Shewan, Marc Tessier-Lavigne, Mu-ming Poo, Christine Holt, Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1 Nature. ,vol. 401, pp. 69- 73 ,(1999) , 10.1038/43441
Yasutomi Nishizuka, Protein kinase C and lipid signaling for sustained cellular responses. The FASEB Journal. ,vol. 9, pp. 484- 496 ,(1995) , 10.1096/FASEBJ.9.7.7737456
Stephen J. A. Davies, Michael T. Fitch, Stacey P. Memberg, Alison K. Hall, Geoffrey Raisman, Jerry Silver, Regeneration of adult axons in white matter tracts of the central nervous system Nature. ,vol. 390, pp. 680- 683 ,(1997) , 10.1038/37776