In vitro metabolism of 17α-ethynylsteroids
作者： Firyal S. Khan , K. Potherby
DOI: 10.1016/0022-4731(79)90332-7
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摘要: Abstract The rates of metabolism synthetic gestagens derived from 19-nortestosterone by rabbit liver tissue in vitro were compared. Over a period 1 h norethisterone was metabolised as rapidly whereas d -norgestrel and lynestrenol at slightly lower rate. Less than 5% l metabolised. In all cases the reaction product tetrahydrosteroid. Lynestrenol through norethisterone. Skeletal muscle, lung small intestine also but slower rate tissue. Small amounts adipose heart spleen inactive. not any extra-hepatic tissues studied.
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sci-hub.se 参考文章(20)
Tomkins Gm, Enzymatic mechanisms of hormone metabolism. I. Oxidation-reduction of the steroid nucleus. Recent Progress in Hormone Research. ,vol. 12, pp. 125- ,(1956)
Gordon M. Tomkins, Patricia J. Michael, THE ENZYMATIC REDUCTION OF Δ4-3-KETOSTEROIDS Journal of Biological Chemistry. ,vol. 225, pp. 13- 24 ,(1957) , 10.1016/S0021-9258(18)64906-3
K. Fotherby, A. Colas, S. M. Atherden, G. F. Marrian, The isolation of 16α-hydroxydehydroepiandrosterone (3β:16α-dihydroxyandrost-5-en-17-one) from the urine of normal men Biochemical Journal. ,vol. 66, pp. 664- 669 ,(1957) , 10.1042/BJ0660664
Patricia Zeis Thomas, Ralph I. Dorfman, Metabolism in Vitro of Androst-4-ene-3,17-dione-4-14C by Rabbit Skeletal Muscle Strips ISOLATION OF TESTOSTERONE-14C, 5α-ANDROSTANE-3,17-DIONE-14C, AND 3β-HYDROXY-5α-ANDROSTAN-17-ONE-14C Journal of Biological Chemistry. ,vol. 239, pp. 762- 765 ,(1964) , 10.1016/S0021-9258(18)51655-0
John J. Schneider, Patricia M. Horstmann, EFFECTS OF INCUBATING COMPOUND E AND RELATED STEROIDS WITH VARIOUS SURVIVING RAT TISSUES Journal of Biological Chemistry. ,vol. 196, pp. 629- 639 ,(1952) , 10.1016/S0021-9258(19)52397-3
Samuel F. Sisenwine, Hazel B. Kimmel, Ann L. Liu, Hans W. Ruelius, Stereoselective biotransformations of dl-norgestrel and its enantiomers in the African green monkey. Drug Metabolism and Disposition. ,vol. 2, pp. 65- 70 ,(1974)
BA Cooke, DK Vallance, Metabolism of megestrol acetate and related progesterone analogues by liver preparations in vitro Biochemical Journal. ,vol. 97, pp. 672- 677 ,(1965) , 10.1042/BJ0970672
A. MAZAHERI, K. FOTHERBY, J. R. CHAPMAN, Metabolism of lynestrenol to norethisterone by liver homogenate. Journal of Endocrinology. ,vol. 47, pp. 251- 252 ,(1970) , 10.1677/JOE.0.0470251
W. Nienstedt, K. Hartiala, Steroid Metabolism by the Canine Intestine Scandinavian Journal of Gastroenterology. ,vol. 4, pp. 483- 488 ,(1969) , 10.3109/00365526909180638
E.M. Chambaz, E.C. Horning, Conversion of steroids to trimethylsilyl derivatives for gas phase analytical studies: reactions of silylating reagents. Analytical Biochemistry. ,vol. 30, pp. 7- 24 ,(1969) , 10.1016/0003-2697(69)90368-6