In vivo role of truncated trkb receptors during sensory ganglion neurogenesis.
作者： B.W Luikart , S Nef , T Shipman , L.F Parada
DOI: 10.1016/S0306-4522(02)00719-4
关键词:
摘要: The mammalian trkB locus undergoes alternative splicing to produce two different types of brain-derived neurotrophic factor receptors. first type is the full-length receptor tyrosine kinase (TrkB(Tk+); second a truncated lacking intracellular domain (TrkB(Tk-)). To investigate function both TrkB in vivo, we have generated knockout mice all isoforms (trkB-/-) and compared sensory neuron survival these that previously described (trkB(k)-/-). We observed presence receptors trkB(k)-/- results more severe losses. Increased losses associated with were most regions where dependent on neurotrophin-3. Our data suggest negatively influence by interfering catalytic
elsevier.com
utsystem.edu参考文章(41)
Timothy J. Roper, Olfaction in birds Advances in The Study of Behavior. ,vol. 28, pp. 247- 332 ,(1999) , 10.1016/S0065-3454(08)60219-3
R. Klein, L.F. Parada, F. Coulier, M. Barbacid, trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. The EMBO Journal. ,vol. 8, pp. 3701- 3709 ,(1989) , 10.1002/J.1460-2075.1989.TB08545.X
N. Ninkina, J. Adu, A. Fischer, L. G. Piñón, V. L. Buchman, A. M. Davies, Expression and function of TrkB variants in developing sensory neurons. The EMBO Journal. ,vol. 15, pp. 6385- 6393 ,(1996) , 10.1002/J.1460-2075.1996.TB01029.X
Mary Ellen Palko, Vincenzo Coppola, Lino Tessarollo, Evidence for a Role of Truncated trkC Receptor Isoforms in Mouse Development The Journal of Neuroscience. ,vol. 19, pp. 775- 782 ,(1999) , 10.1523/JNEUROSCI.19-02-00775.1999
D S Middlemas, R A Lindberg, T Hunter, trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Molecular and Cellular Biology. ,vol. 11, pp. 143- 153 ,(1991) , 10.1128/MCB.11.1.143
Leslayann C. Schecterson, Mark Bothwell, Neurotrophin and neurotrophin receptor mRNA expression in developing inner ear Hearing Research. ,vol. 73, pp. 92- 100 ,(1994) , 10.1016/0378-5955(94)90286-0
Jason T. Rifkin, Valerie J. Todd, Lawrence W. Anderson, Frances Lefcort, Dynamic Expression of Neurotrophin Receptors during Sensory Neuron Genesis and Differentiation Developmental Biology. ,vol. 227, pp. 465- 480 ,(2000) , 10.1006/DBIO.2000.9841
John S. Rudge, Yanping Li, Elizabeth M. Pasnikowski, Karen Mattsson, Li Pan, George D. Yancopoulos, Stanley J. Wiegand, Ronald M. Lindsay, Nancy Y. Ip, Neurotrophic factor receptors and their signal transduction capabilities in rat astrocytes. European Journal of Neuroscience. ,vol. 6, pp. 693- 705 ,(1994) , 10.1111/J.1460-9568.1994.TB00981.X
Steven G Kernie, Daniel J Liebl, Luis F Parada, BDNF regulates eating behavior and locomotor activity in mice. The EMBO Journal. ,vol. 19, pp. 1290- 1300 ,(2000) , 10.1093/EMBOJ/19.6.1290
Rüdiger Klein, Inmaculada Silos-Santiago, Richard J. Smeyne, Sergio A. Lira, Riccardo Brambilla, Sherri Bryant, Li Zhang, William D. Snider, Mariano Barbacid, Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements Nature. ,vol. 368, pp. 249- 251 ,(1994) , 10.1038/368249A0