Another Flaw in the Linearized Multistage Model Upper Bounds on Human Cancer Potency

摘要: The statistical methodology used by the EPA and other federal agencies to characterize human cancer potencies based on animal experiments greatly exaggerates estimates bounds for risks in some instances. current incorporates simplified assumptions approximations that fail properly assess impact of quantitative differences experimental background transition rates from stage multistage carcinogenic process. Because majority tumorigenic responses rats mice occur organs with a high tumor incidence and, hence, rates, often significantly overstates risk. This newly recognized flaw conjunction several previously flaws characterizations argues strongly change away solely default screening more comprehensive, biologically risk assessment methodology.