作者: Donald Evenson , Regina Wixon
DOI: 10.1016/S1472-6483(10)62000-7
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摘要: Meta-analyses were conducted to investigate the relationship of sperm DNA fragmentation on pregnancy outcome using in-vivo fertilization, IUI, routine IVF and ICSI. Couples with no known infertility problems 7.0 times (CI 3.17, 17.7) more likely achieve a pregnancy/delivery if index (DFI) was <30% (n = 362, P 0.0001) fertilization. Infertile couples IUI 7.3 2.88, 18.3) their DFI 518, 0.0001). With IVF, infertile approximately 2.0 1.02, 2.84) become pregnant 381, 0.03). For ICSI and/or results showed non-significant trend where 1.6 0.92, 2.94) 323,P 0.06). The meta-analyses similar, indicating that patients have as good statistical probability obtaining presumably fertile same DFI. These show Sperm Chromatin Structure Assay test significantly predictive for reduced success in-vivo, lesser extent