Induction of various cytokines and development of severe mucosal inflammation by cagA gene positive Helicobacter pylori strains
作者： Y Yamaoka , M Kita , T Kodama , N Sawai , K Kashima
DOI: 10.1136/GUT.41.4.442
关键词:
摘要: Background —Helicobacter pylori strains possessing the cagA gene are thought to induce interleukin 8 (IL-8) in gastric mucosa. However, it is still unclear whether a relation exists between and expression patterns of cytokines other than IL-8. Aims — To investigate production various cytokine proteins using an enzyme linked immunosorbent assay (ELISA). Patients methods In 184 patients, was detected by polymerase chain reaction (PCR), levels IL-1β, IL-6, IL-7, IL-8, IL-10, tumour necrosis factor α (TNF-α) antral biopsy specimens were measured ELISA. Results— Mucosal TNF-α significantly higher H positive negative patients. Furthermore, mucosal IL-1β IL-8 infected with those strains. level closely correlated that (p Conclusion— These findings suggest ability differs among strains; + kinds may cause severe inflammation, whereas − only weakly mild inflammation. as most patients have gastritis, these not be equivalent ulcerogenic
sci-hub.se 参考文章(29)
J Huang, P W O'Toole, P Doig, T J Trust, Stimulation of interleukin-8 production in epithelial cell lines by Helicobacter pylori. Infection and Immunity. ,vol. 63, pp. 1732- 1738 ,(1995) , 10.1128/IAI.63.5.1732-1738.1995
Y Yamaoka, M Kita, T Kodama, N Sawai, J Imanishi, Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa Gastroenterology. ,vol. 110, pp. 1744- 1752 ,(1996) , 10.1053/GAST.1996.V110.PM8964399
Murali K.R. Tummuru, Smita A. Sharma, Martin J. Blaser, Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL‐8 in gastric epithelial cells Molecular Microbiology. ,vol. 18, pp. 867- 876 ,(1995) , 10.1111/J.1365-2958.1995.18050867.X
Y. Yamaoka, M. Kita, T. Kodama, N. Sawn, K. Kashima, J. Imanishi, Expression of Cytokine mRNA in Gastric Mucosa with Helicobacter pylori Infection Scandinavian Journal of Gastroenterology. ,vol. 30, pp. 1153- 1159 ,(1995) , 10.3109/00365529509101624
M K Tummuru, T L Cover, M J Blaser, Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production. Infection and Immunity. ,vol. 61, pp. 1799- 1809 ,(1993) , 10.1128/IAI.61.5.1799-1809.1993
H Nakamura, K Yoshimura, N G McElvaney, R G Crystal, Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. Journal of Clinical Investigation. ,vol. 89, pp. 1478- 1484 ,(1992) , 10.1172/JCI115738
R de Waal Malefyt, J Abrams, B Bennett, C G Figdor, J E de Vries, Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. Journal of Experimental Medicine. ,vol. 174, pp. 1209- 1220 ,(1991) , 10.1084/JEM.174.5.1209
M. Suzuki, S. Miura, M. Suematsu, D. Fukumura, I. Kurose, H. Suzuki, A. Kai, Y. Kudoh, M. Ohashi, M. Tsuchiya, Helicobacter pylori-associated ammonia production enhances neutrophil-dependent gastric mucosal cell injury. American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 263, pp. 719- 725 ,(1992) , 10.1152/AJPGI.1992.263.5.G719
P Gionchetti, D Vaira, M Campieri, John Holton, Marcello Menegatti, A Belluzzi, Elisabetta Bertinelli, Maurizio Ferretti, C Brignola, Mario Miglioli, Luigi Barbara, Enhanced mucosal interleukin-6 and -8 in Helicobacter pylori-positive dyspeptic patients The American Journal of Gastroenterology. ,vol. 89, pp. 883- 887 ,(1994)
Erik A.J. Rauws, Wies Langenberg, Hendrik J. Houthoff, H.C. Zanen, Guido N.J. Tytgat, Campylobacter pyloridis-associated chronic active antral gastritis. Gastroenterology. ,vol. 94, pp. 33- 40 ,(1988) , 10.1016/0016-5085(88)90606-3