Biochemical markers of hepatic fibrosis

摘要: Most liver diseases lead to a pathobiochemical reaction termed fibrosis. This is dynamic process implying different rates of progression or regression. Thus, histological examination biopsy essential for diagnosis but biochemical tests are necessary assessing the activity and monitoring its evolution. We review most important constituents connective tissue developed evaluating The aminopeptide type III procollagen widely used parameter: two radioimmunoassays have been with affinities circulating forms molecule. determination serum P3P reveals an elevation blood levels both in acute chronic diseases. In first, index hepatic necrosis inflammation which correlates other parameters. second it active fibrogenesis. Moreover, primary biliary cirrhosis this parameter independent prognostic variable predictor survival. Other immunoassays exist collagen cleavage products, their clinical value not established. Laminin fibronectin principal structural glycoproteins liver. Fibronectin does seem be disease. contrast, laminin severity portal venous pressure advanced Its concentration parallels varices may indicate risk bleeding. Hyaluronate high molecular weight polysaccharide, raised concentrations reflect increased synthesis by activated fibroblasts impaired catabolism useful measurement prolyl 4-hydroxylase as well that lysine oxidase enzymes has proposed, sufficiently demonstrated. A panel (e.g., laminin, hyaluronate procollagen) seems recommended assessment fibrosis practice.