Steps toward the percutaneous replacement of atrioventricular valves : An experimental study

摘要: Objectives The goal of this study was to develop a device for percutaneous replacement the tricuspid valve in animals. Background Percutaneous has recently been introduced, and early clinical experience reported. To date, technique is limited pulmonary aortic valves selected patients. Methods A newly designed nitinol stent, forming two large disks separated by cylinder with diameter 18 mm, specially purpose study. An 18-mm bovine mounted central part polytetrafluoroethylene membrane sutured onto ventricular disk. Eight ewes were equally divided into groups (group 1, acute study; group 2, killed at one month). Results Seven eight devices successfully delivered desired position. In animal, trapped cordae, leading its incomplete opening. significant paravalvular leak noticed animal 2. Mean right atrial pressure increased from 5 7 mm Hg did not change during follow-up. At autopsy, examination confirmed good position implanted Conclusions Implantation semi-lunar possible through transcatheter approach. disk-based stent needed allow implantation atrioventricular These studies open new perspectives as well mitral replacement.