A Combination Therapy with Baicalein and Taxol Promotes Mitochondria-Mediated Cell Apoptosis: Involving in Akt/β-Catenin Signaling Pathway
作者： Qiong Pan , Min Xue , Song-shu Xiao , Ya-jun Wan , Da-bao Xu
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摘要: Baicalein, a major flavonoid, possesses anticancer and anti-inflammatory activity. The aim of the study is to explore efficiency combination therapy with baicalein taxol, as well molecular mechanism on antitumor Human ovarian cancer cells were treated different concentration for 48 h, cell viability was determined by MTT assay. Baicalein inhibited proliferation cells, IC50 value in A2780 SKOV3 OVCAR 46.23, 60.68, 38.03 μM, respectively. 10 μM combined increasing taxol results demonstrated that had much higher effects compared monotherapy. mechanisms involving promoted caspase-3 activity then leading cleavage poly-ADP-ribose polymerase, which increased apoptosis c...
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