Delivery of baicalein and paclitaxel using self-assembled nanoparticles: synergistic antitumor effect in vitro and in vivo
作者： Fansheng Kong , Wei Wang , Mei Xi , Xuezhong Duan , Yong Wang
DOI: 10.2147/IJN.S80297
关键词:
摘要: PURPOSE Combination anticancer therapy is promising to generate synergistic effects maximize the treatment effect and overcome multidrug resistance. The aim of study reported here was develop multifunctional, dual-ligand, modified, self-assembled nanoparticles (NPs) for combination delivery baicalein (BCL) paclitaxel (PTX) prodrugs. METHODS Prodrug PTX prodrug BCL, containing dual-targeted ligands folate (FA) hyaluronic acid (HA), were synthesized. Multifunctional NPs BCL (PTX-BCL) prepared antitumor evaluated in vitro vivo. transfection efficiency novel modified vectors human lung cancer A549 cells drug-resistant A549/PTX cells. vivo systemic toxicity different formulations further investigated mice bearing xenografts. RESULTS size PTX-BCL approximately 90 nm, with a positive zeta potential +3.3. displayed remarkably better activity over wide range drug concentrations, showed an obvious synergism CI50 values 0.707 0.513, indicating that double-ligand modification co-delivery prodrugs had remarkable superiority other formulations. CONCLUSION NP drug-delivery system proven efficient by its targeting delivering Enhanced achieved NPs, resistance this targeted nanomedicine.
sci-hub.se 参考文章(63)
Wim H De Jong, Paul JA Borm, Drug Delivery and Nanoparticles:applications and Hazards International Journal of Nanomedicine. ,vol. 3, pp. 133- 149 ,(2008) , 10.2147/IJN.S596
Hiroki Takahashi, Monica C Chen, Diane M Harris, Hung Pham, Howard A Reber, Oscar J Hines, Vay Liang W Go, Guido Eibl, None, Anti-Apoptotic BCL-2 Family Protein MCL-1 Plays a Critical Role in Baicalein-Induced Apoptosis in Human Pancreatic Cancer Cells Gastroenterology. ,vol. 140, pp. S- 684 ,(2011) , 10.1016/S0016-5085(11)62838-2
Xiaopin Duan, Jisheng Xiao, Qi Yin, Zhiwen Zhang, Haijun Yu, Shirui Mao, Yaping Li, Smart pH-sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram. ACS Nano. ,vol. 7, pp. 5858- 5869 ,(2013) , 10.1021/NN4010796
Twan Lammers, Vladimir Subr, Karel Ulbrich, Wim E. Hennink, Gert Storm, Fabian Kiessling, Polymeric nanomedicines for image-guided drug delivery and tumor-targeted combination therapy Nano Today. ,vol. 5, pp. 197- 212 ,(2010) , 10.1016/J.NANTOD.2010.05.001
Hong Yeol Yoon, Hyun Ryoung Kim, Gurusamy Saravanakumar, Roun Heo, Su Young Chae, Wooram Um, Kwangmeyung Kim, Ick Chan Kwon, Jun Young Lee, Doo Sung Lee, Jae Chan Park, Jae Hyung Park, Bioreducible hyaluronic acid conjugates as siRNA carrier for tumor targeting. Journal of Controlled Release. ,vol. 172, pp. 653- 661 ,(2013) , 10.1016/J.JCONREL.2013.09.008
Kanwaldeep K. Gill, Amal Kaddoumi, Sami Nazzal, Mixed micelles of PEG(2000)-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines. European Journal of Pharmaceutical Sciences. ,vol. 46, pp. 64- 71 ,(2012) , 10.1016/J.EJPS.2012.02.010
Cong Luo, Jin Sun, Bingjun Sun, Zhonggui He, None, Prodrug-based nanoparticulate drug delivery strategies for cancer therapy Trends in Pharmacological Sciences. ,vol. 35, pp. 556- 566 ,(2014) , 10.1016/J.TIPS.2014.09.008
J.-G. Shiah, Y. Sun, P. Kopečková, C.M. Peterson, R.C. Straight, J. Kopeček, Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer–doxorubicin/mesochlorin e6-OV-TL 16 antibody immunoconjugates Journal of Controlled Release. ,vol. 74, pp. 249- 253 ,(2001) , 10.1016/S0168-3659(01)00325-X
Z Duan, D.E Lamendola, R.T Penson, K.M Kronish, M.V Seiden, Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-2OS human osteosarcoma cells. Cytokine. ,vol. 17, pp. 234- 242 ,(2002) , 10.1006/CYTO.2001.1008
T H Tsai, S C Liu, P L Tsai, L K Ho, A Y C Shum, C F Chen, The effects of the cyclosporin A, a P-glycoprotein inhibitor, on the pharmacokinetics of baicalein in the rat: a microdialysis study. British Journal of Pharmacology. ,vol. 137, pp. 1314- 1320 ,(2002) , 10.1038/SJ.BJP.0704959