Which one performs better for targeted lung cancer combination therapy: pre- or post-bombesin-decorated nanostructured lipid carriers?
作者： Jiahui Du , Ling Li
DOI: 10.3109/10717544.2015.1099058
关键词:
摘要: AbstractPurpose: The co-delivery of gene and drugs has the potential to treat cancer. aim this study was compare post-bombesin decorated nanostructured lipid carriers (NLC) carrying both doxorubicin (DOX) DNA with pre-bombesin NLC for lung cancer therapy.Methods: Post-bombesin were prepared by two steps. First, DOX DNA-loaded (DOX-DNA-NLC) prepared. Second, Bombesin-NH2 (BN-NH2) added into DOX-DNA-NLC react stearic acid-polyethylene glycol-COOH (SA-PEG-COOH) loaded in NLC. Pre-bombesin Bombesin (BN)-conjugated ligands synthesized. BN Their average size, zeta potential, drug loading evaluated. NCl-H460 human non-small cells (NCl-H460 cells) used testing vitro transfection efficiency cytotoxicity. In vivo anti-tumor effect evaluated on mice beari...
sci-hub.se 参考文章(47)
Fansheng Kong, Wei Wang, Mei Xi, Xuezhong Duan, Yong Wang, Delivery of baicalein and paclitaxel using self-assembled nanoparticles: synergistic antitumor effect in vitro and in vivo International Journal of Nanomedicine. ,vol. 10, pp. 3737- 3750 ,(2015) , 10.2147/IJN.S80297
A MALZERTFREON, S VRIGNAUD, P SAULNIER, V LISOWSKI, J BENOIT, S RAULT, Formulation of sustained release nanoparticles loaded with a tripentone, a new anticancer agent. International Journal of Pharmaceutics. ,vol. 320, pp. 157- 164 ,(2006) , 10.1016/J.IJPHARM.2006.04.007
Hyeona Yim, Sin-jung Park, You Han Bae, Kun Na, Biodegradable cationic nanoparticles loaded with an anticancer drug for deep penetration of heterogeneous tumours. Biomaterials. ,vol. 34, pp. 7674- 7682 ,(2013) , 10.1016/J.BIOMATERIALS.2013.06.058
Abdolrasoul Hejri, Alireza Khosravi, Kamaladin Gharanjig, Mohammadamin Hejazi, Optimisation of the formulation of β-carotene loaded nanostructured lipid carriers prepared by solvent diffusion method Food Chemistry. ,vol. 141, pp. 117- 123 ,(2013) , 10.1016/J.FOODCHEM.2013.02.080
Rohit B. Kolhatkar, Kelly M. Kitchens, Peter W. Swaan, Hamidreza Ghandehari, Surface Acetylation of Polyamidoamine (PAMAM) Dendrimers Decreases Cytotoxicity while Maintaining Membrane Permeability Bioconjugate Chemistry. ,vol. 18, pp. 2054- 2060 ,(2007) , 10.1021/BC0603889
Ken-ichi Ogawara, Keita Un, Ken-ichi Tanaka, Kazutaka Higaki, Toshikiro Kimura, In vivo anti-tumor effect of PEG liposomal doxorubicin (DOX) in DOX-resistant tumor-bearing mice: Involvement of cytotoxic effect on vascular endothelial cells. Journal of Controlled Release. ,vol. 133, pp. 4- 10 ,(2009) , 10.1016/J.JCONREL.2008.09.008
Jingjing Luan, Xiaoye Yang, Lianjun Chu, Yanwei Xi, Guangxi Zhai, PEGylated long circulating nanostructured lipid carriers for Amoitone B: Preparation, cytotoxicity and intracellular uptake joint international conference on information sciences. ,vol. 428, pp. 49- 56 ,(2014) , 10.1016/J.JCIS.2014.04.036
Ling Yuan, Zhen-hai Zhang, Cao Wei, Lei Zhou, Qingqing Wu, Chen, Effect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine International Journal of Nanomedicine. ,vol. 7, pp. 4581- 4591 ,(2012) , 10.2147/IJN.S34991
Jooyeon Ahn, Yutaka Miura, Naoki Yamada, Tsukasa Chida, Xueying Liu, Ahram Kim, Ryuta Sato, Ryo Tsumura, Yoshikatsu Koga, Masahiro Yasunaga, Nobuhiro Nishiyama, Yasuhiro Matsumura, Horacio Cabral, Kazunori Kataoka, Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer Biomaterials. ,vol. 39, pp. 23- 30 ,(2015) , 10.1016/J.BIOMATERIALS.2014.10.069
Jiang, Sun, Yin, Zhou, Ge, Liu, Fansheng Kong, Comparison of two kinds of nanomedicine for targeted gene therapy: premodified or postmodified gene delivery systems International Journal of Nanomedicine. ,vol. 7, pp. 2019- 2031 ,(2012) , 10.2147/IJN.S30928