Pharmacologically active biphosphonates, process for the preparation thereof and pharmaceutical compositions therefrom

摘要: Biphosphonic acids of general formula I: ##STR1## in which R is a fluorine atom linear or branched alkyl radical containing between 1 and 5 carbon atoms, may also be substituted by one more amino groups atoms both R' hydroxy fluorine, their salts with an alkali metal, organic base basic aminoacid, exhibit valuable properties the treatment urolithiasis as inhibitors bone reabsorption. The compound 4-amino-1-hydroxybutan-1,1-biphosphonic acid 100 300 times active than Cl2 MDP.