Distribution, elimination, and action of d-tubocurarine in neonates, infants, children, and adults.

摘要: The relation of plasma concentration d-tubocurarine (dTc) to neuromuscular blockade, and the distribution urinary excretion dTc was determined in neonates (n = 4), infants 6), children 8), adults 8). concentration-time course curves 24 hr are best described for all groups by three-compartment models. Both exhibit decreased clearance (CLP), 1.1 +/- 0.08 1.0 0.06 ml X kg-1 min-1, addition a prolonged t1/2 terminal phase, 311 44 306 35 (mean SEM, min). neonates' 24-hr excretion, 27 2 % total dose) is significantly less than adult value, 45 4% dose. There no significant difference seen log concentration-evoked compound electromyogram (ECEMG) response between 20-80% paralysis adults, children, infants, five seven studied. Two had shift their concentration-response curve right. also any time 50% return ECEMG stimulus height or required recovery from 25 75% control value.