Accelerated onset and delayed recovery of d-tubocurarine blockade with pancuronium in infants and children

摘要: The effect of age on the onset and duration action a d-tubocurarine (DTC) neuromuscular blockade with without pancuronium priming in children was examined. Sixty ASA physical status I or II patients three ranges (0-1 yr, 1-3 yr 3-10 yr) were anaesthetized thiopentone, halothane nitrous oxide. Each patient received either single paralyzing dose DTC 0.4 mg.kg-1, 0.36 mg.kg-1 preceded minutes earlier by 0.007 mg.kg-1. Evoked force contraction adductor pollicis measured using train-of-four stimulation applied every 12 sec. Time to 90 per cent first twitch depression after increased increasing (r = 0.65, p less than 0.01), 1.6 min (SEM +/- 0.3) 0-1 group, 1.9 0.3 (1-3 yr), 5.2 1.2 (3-10 yr). ten spontaneous recovery shorter older individuals 0.40, 0.05), being 36.4 5.1 infants 30.6 4.6 24.0 2.7 Priming accelerated significantly all groups T1 occurring at 0.7 0.1 0.9 2.1 0.6 However, delayed recovery, especially infants.(ABSTRACT TRUNCATED AT 250 WORDS)