Clonality and intracellular polyploidy in virus evolution and pathogenesis

摘要: In the present article we examine clonality in virus evolution. Most viruses retain an active recombination machinery as a potential means to initiate new levels of genetic exploration that go beyond those attainable solely by point mutations. However, despite abundant may be linked molecular events essential for genome replication, herein provide evidence generation recombinants with altered biological properties is not completion replication cycles viruses, and viral lineages (near-clades) can defined. We distinguish mechanistically but inconsequential from evolutionarily relevant recombination, illustrated episodes field during experimental field, has been at origin pathogens, conferred fitness advantages some once parental have attained sufficient degree diversification laboratory, mediated salient segmentation foot-and-mouth disease virus, important animal pathogen whose nature always characterized unsegmented. propose model continuous mutation punctuated, biologically survival both agents promoters cellular Thus, standard evolutionary mode because largely inconsequential, since decisive are dependent on exchange material formation recombinant (mosaic) genomes.