Gamma delta T cells inhibit in vitro growth of the asexual blood stages of Plasmodium falciparum by a granule exocytosis-dependent cytotoxic pathway that requires granulysin.

摘要: Several reports have stated the ability of gamma delta T cells to inhibit growth asexual blood stages Plasmodium falciparum in vitro. However, little information is available about mechanisms involved. In this study, vitro systems were used study role granule exocytosis-dependent cytotoxic pathway inhibition/killing P. by human cells. Our results show that inhibition requires cell-to-cell contact and kill through a after recognition certain ligands or molecules expressed on surface infected erythrocytes merozoites. The inhibitory capacity was strongly correlated with expression granulysin granules, while non-inhibitory CD4+ CD8+ very little, implicating for parasite inhibition. This further suggested addition neutralizing anti-granulysin antibodies, which abrogated Taken together, our suggest based presence essential maintain efficient killing.