The role of platelets in the tumor microenvironment: From solid tumors to leukemia.

摘要: Platelets are increasingly being recognized for promoting tumor growth and metastasis. Many cells derived from solid tumors have the ability to aggregate platelets, this correlates with their metastatic potential. Over past half century, our understanding of cell-induced platelet aggregation (TCIPA) has grown beyond simple concept that cell-containing microthrombi mechanically embolize microvasculature. Tumor cell-activated platelets secrete a multitude factors reciprocally act on cells, as well other within microenvironment; thus, affecting both parenychma tumor-associated stroma. In review, we summarize current knowledge cell-platelet interactions influence microenvironment, including how these impact neoplastic epithelial endothelial pericytes, fibroblasts, immune early niches. addition, review platelet-cancer cell hematological malignancies speculate may leukemic microenvironment. This article is part Special Issue entitled: Microenvironment Regulation Cancer Cell Survival, Metastasis, Inflammation, Immune Surveillance edited by Peter Ruvolo Gregg L. Semenza.