Role of platelets in cancer and cancer-associated thrombosis: Experimental and clinical evidences.

摘要: The primary hemostatic function of platelets has been recognized for more than a century, but increasing experimental and clinical evidences suggest that are also important mediators cancer. Cancer indeed influences platelet physiology, activated participate in each step cancer development by promoting tumor growth, angiogenesis, metastasis, cancer-associated thrombosis. Based on both the results numerous models addressing involvement progression epidemiologic studies use anti-platelet drugs to prevent cancer, have proposed as potential target reduce short-term risk dissemination mortality. However, thrombosis bleeding due not enough evaluated models. Therefore, interesting contribution requires standardization preclinical