Cyclic anticoagulant peptides
作者： John L. Krstenansky , Simon J. T. Mao
DOI:
关键词:
摘要: This invention relates to cyclic peptide derivatives which are useful anticoagulant agents.
lens.org 参考文章(10)
Ursula Seemuller, Hans Fritz, Johannes Dodt, Ernst Fink, Hirudin-PA and its derivatives, process for manufacturing these and the use of these substances ,(1985)
Martin Kramer, Dominique Tripier, Novel polypeptides with a blood coagulation-inhibiting action, processes for their preparation and isolation, their use and agents containing them ,(1986)
John L. Krstenansky, Thomas J. Owen, Mark T. Yates, Simon J.T. Mao, Design, synthesis and antithrombin activity for conformationally restricted analogs of peptide anticoagulants based on the C-terminal region of the leech peptide, hirudin. Biochimica et Biophysica Acta. ,vol. 957, pp. 53- 59 ,(1988) , 10.1016/0167-4838(88)90156-2
Simon J.T. Mao, Mark T. Yates, Dale T. Blankenship, Alan D. Cardin, John L. Krstenansky, Walter Lovenberg, Richard L. Jackson, Rapid purification and revised amino-terminal sequence of hirudin: a specific thrombin inhibitor of the bloodsucking leech. Analytical Biochemistry. ,vol. 161, pp. 514- 518 ,(1987) , 10.1016/0003-2697(87)90482-9
R. P. Harvey, E. Degryse, L. Stefani, F. Schamber, J. P. Cazenave, M. Courtney, P. Tolstoshev, J. P. Lecocq, Cloning and expression of a cDNA coding for the anticoagulant hirudin from the bloodsucking leech, Hirudo medicinalis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 1084- 1088 ,(1986) , 10.1073/PNAS.83.4.1084
Joachim Prof. Dr. Engels, Paul Dr. Habermann, Dieter Dr. Brauer, Friedrich Dr. Wengenmayer, Eugen Dr. Uhlmann, Genetic engineering process for the production of hirudins, and agents for carrying out said process ,(1985)
Reinhard Dr. Maschler, Fritz Raschdorf, Markus Gerhard Dr. Grütter, Verena Steiner, Novel polypeptides with an anticoagulant activity ,(1989)
Hans Fritz, Ernst Fink, Johannes Dodt, Ursula Seemuller, Process for the preparation of desulfatohirudins ,(1984)
John D. Roberts, Organic Chemistry (2nd Edition) California Institute of Technology. ,(1964)