Hirudin-PA and its derivatives, process for manufacturing these and the use of these substances
作者： Ursula Seemuller , Hans Fritz , Johannes Dodt , Ernst Fink
DOI:
关键词: Blood conservation 、 Hirudo medicinalis 、 Stereochemistry 、 Reagent 、 Combinatorial chemistry 、 Thrombin 、 Chemistry 、 Hirudin PA
摘要: The present invention relates to a new content substance found in leeches (Hirudo medicinalis), the derivatives of this abbreviated at N-terminus and C-terminus, desulfated therefrom as well process for production these compounds, their use. These compounds possess thrombin-inhibiting properties can be used inhibit clotting human animals, blood conservation, or reagents analytical determination thrombin.
google.de 参考文章(1)
Hans Prof. Dr. Fritz, Ernst Prof. Dr.Dr. Fink, Ursula Dr. Seemüller, Johannes Dipl.-Chem. Dodt, Desulfatohirudine, process for its preparation and pharmaceutical agent ,(1984)