Analogs of hirudin
作者： Cecilia S. L. Ku , Julian P. Breillatt , Richard Johnson
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摘要: A tyrosine-substituted hirudin analog has antithrombogenic activity. Further simultaneous reaction at native tyrosine residues is prevented by mutation those sites to encode nonreactive amino acids. Several novel strategies for coupling the solid surfaces while simultaneously conserving activity are disclosed.
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